For DOS games, application's, etc that have DOS4GW built in
with the .EXE. Examples being DOOM.EXE and DOOM2.EXE, then do the
following.
\F
- Type: PMWSETUP PMODEW.EXE
- Change the Low Memory Reserve option to FFFF
- Exit the setup program
- Backup your executable, then get back into the PMODE
  directory
- Type: PMWBIND /R d:\path\whatever.exe where d:\path\ is the path to
  your .EXE file.
- Test your application to make sure it work's :-)

For DOS games, application's, etc that have DOS4GW.EXE seperately with the 
program. Examples being Cubic Player v1.6 and X-COM, then do the
following.

- Type: PMWSETUP PMODEW.EXE
- Change the Low Memory Reserve option to FFFF
- Exit the setup program
- Backup your executable, e.g for Cubic Player you would back up
  CP.EXE, and DOS4GW.EXE, then get back into the PMODE directory
- Type: PMWBIND /R d:\path\whatever.exe where d:\path\ is the path to
  your .EXE file, e.g a example being you would patch
  CP.EXE(Cubic Player) instead of DOS4GW.EXE
- Test your application to make sure it work's :-)